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Index > Protein center > CREB1(Gene name) > Bovine
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  • CREB1 (Gene name),
  • Cyclic AMP-responsive element-binding protein 1 (Protein name ),  CREB1_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CREB1(CREB;CREB2);
    Protein name:
    Cyclic AMP-responsive element-binding protein 1(CREB-1;cAMP-responsive element-binding protein 1);
    Alternative:
    Cyclic AMP-responsive DNA-binding protein;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-117, binds CREBBP. Interacts (phosporylated form) with TOX3. Binds to HIPK2.
    Function:
    This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Implicated in synchronization of circadian rhythmicity.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    325
    Sequence:
    50:
    MESGAENQQS | GDAAVTEAES | QQMTVQAQPQ | IATLAQVSMP | AAHATSSAPT | 
    100:
    VTLVQLPNGQ | TVQVHGVIQA | AQPSVIQSPQ | VQTVQISTIA | ESEDSQESVD | 
    150:
    SVTDSQKRRE | ILSRRPSYRK | ILNDLSSDAP | GVPRIEEEKS | EEETSAPAIT | 
    200:
    TVTVPTPIYQ | TSSGQYIAIT | QGGAIQLANN | GTDGVQGLQT | LTMTNAAATQ | 
    250:
    PGTTILQYAQ | TTDGQQILVP | SNQVVVQAAS | GDVQTYQIRT | APTSTIAPGV | 
    300:
    VMASSPALPT | QPAEEAARKR | EVRLMKNREA | ARECRRKKKE | YVKCLENRVA | 
    325:
    VLENQNKTLI | EELKALKDLY | CHKSD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine CREB-1
    Cat.:
    E1318h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine CREB-1
    Cat.:
    E1318r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine CREB-1
    Cat.:
    E1318m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine CREB-1
    Cat.:
    E1318b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine CREB-1
    Cat.:
    U1318m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine CREB-1
    Cat.:
    U1318h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine CREB-1
    Cat.:
    U1318r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine CREB-1
    Cat.:
    U1318b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine CREB-1
    Cat.:
    P1318Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine CREB-1
    Cat.:
    P1318Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine CREB-1
    Polyclonal Antibody for Bovine CREB-1
    Cat.:
    P1318Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine CREB-1
    Monoclonal Antibody for Bovine CREB-1
    Monoclonal Antibody for Bovine CREB-1
    Monoclonal Antibody for Bovine CREB-1
    Protein for Bovine CREB-1
    Protein for Bovine CREB-1
    Protein for Bovine CREB-1
    Protein for Bovine CREB-1

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    References
    1. 1.
      "Nucleotide sequence of the bovine cyclic-AMP responsive DNA binding protein (CREB2) cDNA."
      Willems L. , Kettmann R. , Chen G. , Portetelle D. , Burny A. , Derse D.
      DNA Seq.1:415-417(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Nucleotide sequence of the CREB protein involved in bovine leukemia virus expression."
      Adam E. , Twizere J.C. , Burny A. , Kettmann R. , Willems L.
      Submitted (1997-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2007-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Hereford.
      tissue: Thymus.
    4. 4.
      "A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat."
      Willems L. , Kettmann R. , Chen G. , Portetelle D. , Burny A. , Derse D.
      J. Virol.66:766-772(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo."
      Adam E. , Kerkhofs P. , Mammerickx M. , Kettmann R. , Burny A. , Droogmans L. , Willems L.
      J. Virol.68:5845-5853(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression."
      Adam E. , Kerkhofs P. , Mammerickx M. , Burny A. , Kettman R. , Willems L.
      J. Virol.70:1990-1999(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism."
      Cammarota M. , Bevilaqua L.R. , Dunkley P.R. , Rostas J.A.
      J. Neurochem.79:1122-1128(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-117
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